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Satoshi Nishimura (M.D., Ph.D)
Department of Cardiovascular Medicine
Translational Systems Biology and Medicine Initiative
The University of Tokyo
Associate Peofessor

 

To elucidate the molecular mechanisms of pathological conditions consisted by the complicated and multi-cellular abnormal interactions in remodeling tissues, an intravital visualization technique, based on laser confocal microscopy was therefore needed and developed.
It enabled us to precisely evaluate the three-dimensional structures in living tissue, and the multi-cellular dynamics in vivo with high time and spatial resolutions. 
Using this technique, we focus on the metabolic syndrome and how obese adipose tissue plays a bad role in obesity. Please enjoy beautiful images and videos IN LIVING ANIMALS. 
At first please click

 
News
New movies can be donwnloaded from Research page!
2011.11.23.

The manuscript below is accepted for "Blood".

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates 
contribution of inflammatory cytokine and integrin signaling

Satoshi Nishimura
1,2, Ichiro Manabe1,2,3, Mika Nagasaki1,4, Shigeru Kakuta9,11,
Yoichiro Iwakura9,12, Naoya Takayama10, Jun Ooehara10, Makoto Otsu10,
Akihide Kamiya10, Brian Petrich13, Tetsumei Urano14, Takafumi Kadono5,
Shinichi Sato5, Atsu Aiba6, Hiroshi Yamashita1, Seiryo Sugiura7, Takashi Kadowaki2,3,8 
Hiromitsu Nakauchi10, Koji Eto10,15, and Ryozo Nagai1,2,3

1Department of Cardiovascular Medicine, 2Translational Systems Biology and Medicine Initiative, 3Global COE Program, Comprehensive Center of Education and Research for Chemical Biology of the Diseases, 4Computational Diagnostic Radiology and Preventive Medicine, 5Department of Dermatology, 6Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, 7Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, 8Department of Metabolic Diseases, The University of Tokyo, Japan; 9Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, and 10Division of Stem Cell Therapy and Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo , Japan ;


2011.10.9. Karada-no Kimochi TV program introduced by my research 


2011.10.1. Tokorosan no me ga ten TV program  introduced by my research 



2011. Satoshi Nishimura is now an associate professor!


My hobby is sport-car driving.
I tested Nissan R35 GT-R, and 911 turbo (997) all day!
The both cars are ... GREAT!

2011. Satoshi Nishimura received three more awards!
2011.11.1. Tokyo Japan Medical Association Research Award
2011. 9.1. Belfast, Northern Ireland, Andor 2011 Insight Award in the Life Sciences category 
2011.8.20-21. Tokyo , 9th Blood and vessel orbis  Young Investigator's Award
2011.7.31.

TBS TV program "Karada no Kimochi" introduced our research works.




2011.5-7.Satoshi Nishimura received three prizes!

2011.7. The 12th US-Japan-Asia Dialogue on Cardiovascular Diseases, Outstanding Best Presenter Award 
2011.6. Japanese Society of Cell Biology Young Investigator's Award, 1st Prize 
2011.5. 54th Annual Meeting of the Japanese Diabetes Society, Young Investigator's Award


2011.5.14.

NHK TV program "TV symposium" introduced our research works.

2011.4.30.
TV program by NHK "Science Zero" introduced our imaging works.


2011.4.23.
TV program by Nihon-TV "Sekai-ichi uketai jugyou." introduced our imaging works.








2011.2.28.
Article regarding our "in vivo imaging" and our labs is in the 1st page of
Nikkan Kogyo Shimbun Newspaper (Buisness & Technology Daily News)


Click to enlarge

2011.2.20.
Satoshi Nishimura was selected for Funding Program for Next Generation World-Leading Researchers!

Satoshi Nishimura was selected for "Grant-in-aid for Scientific Research on Innovative areas
"Fluorescent Live imaging" from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
Satoshi Nishimura was selected for grant  from "Ministry of Health, Labour and Welfare".

2011.1.18

Manuscript, "Transient activation of c-MYC expression is critifal for efficient platelet generation from human induced pluripotent stem cells."
is published in Journal of Experimental Medicine, 2010; 207(13):2817-2830

(Authors: Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, 
Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K. <Manuscript Download> )

This paper is selected for Cover of JEM.
   

This paper is introduced by Editorials of JEM. <Editorial Manuscript Download> 

This paper it introduced by Nature.
    
2009.9.24.

Research was introduced in the book "Oshiete Science" (publisehed by Gijutshu-hyoron sha).


2010.12.1-2.

Satoshi Nishimura received, Excellent Poster Award in The 16th Takeda Science Foundation Symposium on Bioscience 

2010.12.4.

TV program by NHK "Science ZERO" introduced our imaging works.







2010.04.12

Satoshi Nishimura received Research Award of Japanese Society of Biorheology

2010.02.27.

Satoshi Nishimura received additional two awards

2010.2. Inflammation, lipid metabolism, metabolic research forum, Young Investigator Award

2010.2. The Japanese Circulation Society, Young Investigator's Award, 1st Prize

We are now developing novel two-photon based in vivo imaging systems!

2009.12.24.
Newsletter article about JCI paper.
2009.12.24.
Satoshi Nishimura received five awards including "Yagi Awards in Japanese circulation society". 

2010.3. The Japanese Circulation Society, Yagi Award.
2009.12. Olympus BioScapes Digital Imaging Competition, Honorable Mention Award 
2009.11. Japanese Association of Cardiovascular Pharmacology  Young Investigator's Award 
2009.7. International Symposium on Molecular Cell Biology of Macrophages Young Investigator's Award
2009.6 Japanese Society of Cell Biology Young Investigator's Award

2009.11.11.
Our manuscript regarding the in vivo platelet kinetics is accepted for JCI.
Lnk/Sh2b3 regulates integrin alpha-IIb-beta3 outside-in signaling in platelets 
leading to stabilization of developing thrombus in vivo  
Nishimura S*, Takizawa H*, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, 
Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. (*same contribution)
J Clin Invest., 2009, in publication.
2009.10.21
Interview article about our work is now available on the Yokogawa-denki website.
2009.7.27.
NHK TV, TV Asahi broadcast about our Nature Medicine research articles. 
Many news magazines carried the article about our research.

2009.4.14.
Nishimura received "Young Scientist Award, Ministry of Education, Culture, Sports, Science and Technology"!

2009.3.19.
Our manuscript regarding the lymphocyte in obese adipose tissue is accepted for Nature Medicine.
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity 
Satoshi Nishimura1,2,3*, Ichiro Manabe1,2,3*, Mika Nagasaki1,4, Koji Eto5, Hiroshi Yamashita1, 
Mitsuru Ohsugi6, Makoto Otsu5, Kazuo Hara6 Seiryo Sugiura7, Kotaro Yoshimura8, Takashi Kadowaki6, and Ryozo Nagai1
*Corresponding Author

 


Webmaster: Satoshi Nishimura 
(the University of Tokyo, Department of Cardiovascular Medicine)


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